Question

A typical granuloma representing specialist chronic inflammation in a case of tuberculosis. The arrows outline the edges of the granuloma formed by macrophages. It is surrounded by lymphocytes.

Why do you think this is the case? Note also there is central necrosis. Why do you think this basic understanding is useful in predicting and explaining the clinical effects of tuberculosis?

Answer 1

ANSWER :

The chronic inflammation in case of tuberculosis represents granulomatosis in which a granuloma contains immune cells of blood derived and epithelioid cells (differentiated) macrophages surrounded by T-lymphocytes. However caseous granulomas are typical of TB.

It is formed when cells of immune system wall off the toxic substances that could be harmful but unable eliminate them out. But necrosis is caused due to damage or dieing the tissue of a particular area due to toxic factors.