Question

Give examples of two different drugs that could both result in an increase in the level of the same neurotransmitter in the synaptic cleft by different mechanisms.

Answer 1

increase in the level of the Acetylcholine neurotransmitter in the synaptic cleft by

1) Acetylcholine Esterase inhibitor drugs such as neostigmine. These inhibit the Ach degradation by Ach Esterase enzyme and thereby prolonging the stay of Ach in synaptic clefts.

2) parasympathomimetic drug, sometimes called a cholinomimetic drug, is a substance that stimulates the parasympathetic nervous system (PSNS).

Examples : Acetylcholine Bethanecol Carbachol Pilocarpine