Question

During the postabsorptive state, the liver catabolizes lipids and amino acids to produce acetyl-CoA. Which of...

During the postabsorptive state, the liver catabolizes lipids and amino acids to produce acetyl-CoA. Which of the following can build up in the blood when levels of acetyl-CoA in the liver increases?

amino acids

ketone bodies

glycerol

fatty acids

Science   Anatomy-And-Physiology   
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Answer #1

B. Ketone bodies

  • Acetyl CoA normally enter Krebs cycle (TCA Cycle).
  • When the concentration of Acetyl CoA increases (due to executive breakdown of fats) then some of Acetyl CoA enter liver mitochondria and gets converted to ketone bodies (acetone, acetoacetate and beta hydroxybutyrate). This happens because the concentration of Acetyl CoA exceeds to that what TCA cycle can handle.
  • Pathway for ketone body synthesis

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