Question

Place a number (1-7) next to each of the steps given below to put them in the correct chronological order. There are a few processes that happen simultaneously – give them the same number with a sub-letter (e.g. 6a and 6b), but be sure to indicate which numbers are happening at roughly the same time.

1. ___ Binding of glutamate to NMDA receptors

2. ___ Entry of Na+ and exit of K+ from post-synaptic membrane

3. ___ Depolarization of post-synaptic membrane

4. ___ Release of glutamate from pre-synaptic membrane

5. ___ Blockage of NMDA channel by Mg2+

6. ___ Entry of Ca2+ into post-synaptic cell

7. ___ Binding of glutamate to AMPA receptors

8. ___ Opening of AMPA channel

9. ___ Removal of Mg2+ from NMDA channel

10. ___ Opening of NMDA channel

Answer 1

i will put the same no on which line is given answer is .

5. __1_ Blockage of NMDA channel by Mg2+   

4. __2_ Release of glutamate from pre-synaptic membrane

7. __3a_ Binding of glutamate to AMPA receptors

1. __3b_ Binding of glutamate to NMDA receptors

8. __4_ Opening of AMPA channel

2. __5_ Entry of Na+ and exit of K+ from post-synaptic membrane

3. __6_ Depolarization of post-synaptic membrane

9. __7_ Removal of Mg2+ from NMDA channel

10. __8_ Opening of NMDA channel

6. __9_ Entry of Ca2+ into post-synaptic cell

no 7 and 1 are simulatnously occuring

NMDA is already blocked by Mg2+