"Breaking the seal" refers to the notion that if you pee after drinking alcohol , you're breaking some kind of biological seal that will result in you needing to pee excessively for the rest of the night.
There's no such thing as a "seal" that you break when you pee for the first time after drinking alcohol.
Alcohol has diuretic effect on the body, meaning it causes increased urination. Alcohol suppresses a hormone in your body called vasopressin. Vasopressin causes less fluid to pass through kidney filtration, causing less urine production. By suppressing the release of vasopressin, alcohol causes excess urination.
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