Question

Create a drawing that includes:

Hypothalamus

CRH

Anterior Pituitary

Coritcotroph

CRHR

ACTH

Adrenal Cortex

Zona Glomerulosa

Zona Fasciculata

Zona Reticularis

ACTH receptor (Melanocortin Receptor 2, MC₂-R)

Cortisol

GCRs

GC Target Tissues/Organs

Feedback Loops (Including Receptors)

Answer 1

CRH from hypothalamus acts on anterior pituitary gland .Corticotrophs are cells in anterior pituitary to produce pro -opiomelanocortin which undergoes cleavage to form ACTH.Anterior pituitary produces CRHR .ACTH (corticotropin) acts on adrenal glands to release cortisol. Adrenal gland has a cortex and medulla.Cortex have 3 layers. Zona glomerulosa produces aldosterone. Zona fasiculata produces cortisol. Zona reticularis produces sex corticosteroids like testosterone. Glucocorticoid receptors are the receptors that are binding to cortisol. GCR 's target tissues are liver,muscles adipose tissues and pancreas. Feed back loops are regulatory mechanism for cortisol release.When cortisol increases then to regulate it's level ACTH &CRH are released. These act on adrenal glands and anterior pituitary respectively.