Question

How would the following have a direct impact on heart rate and coronary blood flow? 1....

How would the following have a direct impact on heart rate and coronary blood flow?

1. Beta 1 receptor agonist

2. Beta 2 receptor agonist

3. Beta 1 receptor antagonist

4. Beta 2 receptor antagonist

5. Muscarinic receptor agonist

6. Muscarinic receptor antagonist

Science   Anatomy-And-Physiology   
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Answer #1

Beta 1 and 2 receptor agonist activates adenylate cyclase leading to activation of cAMP whuch activates protein kinase A leading to contraction of cardiac tissue. This leads to increase in heart rate and coronary blood flow.

Beta 1 antagonist block binding of epinephrine to receptors decreasing heart rate and blood flow.

Beta 2 antagonist block beta 2 adrenergic receptors decreasing heart rate and blood flow.

Muscarinic agonist activate muscarinic cholinergic receptors decreasing heart rate and blood flow.

Muscarinic antagonist block acetylcholine receptors increasing heart rate and blood flow.

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