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A patient has been diagnosed as having a certain type of epilepsy associated with a lack...

A patient has been diagnosed as having a certain type of epilepsy associated with a lack of GABA. Why would this deficiency lead to the increased and uncontrolled neuronal activity exhibited by the patient's seizures?

Science   Anatomy-And-Physiology   
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Answer #1

* GABA(gamma aminobutyric acid) is a principal inhibitory neurotransmitter in cerebral cortex. GABA controls the neurotransmission by acting on GABAA and GABAB receptors, which controls chloride entry and calcium entries respectively.

* As the patient is having GABA deficiency, it means the calcium entry through voltage gated calcium channels is not retricted leads to release of other neurotransmitters.

* The increase in calcium entry and other neurotransmitters causes the increase of neuronal activity. This causes the epilepsy condition. This condition can be treated by giving anti epileptic drugs.

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