Question

18. The drug carboplatin for ovarian carcinoma is administered intravenously at a dose of 360 mg/m2 except in patients with impaired kidney function. In patients with renal impairment, the dose is reduced by 30%. How many milligrams of carboplatin should be administered to a patient with renal impairment who weighs 110 pounds and is 5'2" in height?

Answer is 373mg, please show the work thank you

Answer 1

W = 110 pounds = 49.9 kgs

H = 5' 2'' feet = 157.5 cm

So that BSA (body surface area) is m^2

And so at the rate of 360 mg/m^2 the dosage would have been

Reducing by 30% as there is renal impairment, the dosage is (rounded above)

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