I agree with GF4L
The best shot of a win would be the best college basketball team beating the worst NBA team in a short series. It's all about getting that ball down the court, and a great college team might be able to get the momentum going in a short series. But I'd still put my money on the NBA team.
Even the best college football team would get tossed around like rag dolls against the Lions.
The MLB players are just too much of an elite talent for the best college team to beat. Even the worst team would outslug them, it would be catastrophic.
Same with Hockey, the worst NHL team again, they would toss around the best college hockey team.